Table 4.
Comparison of baseline characteristics, plasma zonulin levels, and perinatal outcomes according to severity of intrahepatic cholestasis of pregnancy.
| Variables | Mild ICP (n = 80) | Severe ICP (n = 24) | p |
|---|---|---|---|
| Age (years) median (min–max) |
28 (18–41) | 29 (19–41) | 0.169 a |
| BMI (kg/m2) median (min–max) |
27.77 (20.12–39.12) | 29.11 (23.33–39.12) | 0.057 b |
| Gravidity median (min–max) |
1 (1–6) | 1,5 (1–6) | 0.166 b |
| Parity median (min–max) |
0 (0–3) | 0,5 (0–4) | 0.229 b |
| Gestational week of delivery median (min–max) |
38 (35–40) | 36 (34–37) | <0.001 b |
| 1. minute APGAR score median (min–max) |
9 (6–9) | 8 (5–9) | 0.032 b |
| 5. minute APGAR score median (min–max) |
9 (8–10) | 9 (8–10) | 0.404 b |
| Zonulin (ng/mL) | 11.84 (1.77–116.12) | 83.27 (5.81–188.9) | <0.001 b |
| Delivery type (CS/VD) n (%) |
33/47 (41.2%/58.8%) |
7/17 (29.2%/70.8%) |
0.408 c |
| NICU admission n (%) |
0 (0%) |
10 (41.7%) |
<0.001 c |
| Meconium staining n (%) |
2 (2.5%) |
14 (58.3%) |
<0.001 c |
| Birth weight (2500 g–3999 g /≥4000 g/S < 2500 g) n (%) |
75/3/2 (93.8%/3.8%/2.5%) |
13/0/11 (54.2%/0%/45.8%) |
<0.001 c |
The levels of categories are presented as the median (min–max) for numerical variables and as the number of observations and percentile for nominal variables. Values in bold represent statistically significant outcomes. Abbreviations: NICU: newborn intensive care unit CS: Caesarean section VD: vaginal delivery BMI: body mass index. a independent samples t test. b Kruskal–Wallis test. c Pearson chi-squared test.