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First-line treatment options in metastatic CCRC.
| Standard of Care | Alternative in Patients Who Cannot Receive Immunotherapy | |
|---|---|---|
| IMDC favourable risk | Nivolumab/cabozantinib Pembrolizumab/axitinib Pembrolizumab/lenvatinib |
Sunitinib Pazopanib |
| IMDC intermediate and poor risk | Nivolumab/cabozantinib Pembrolizumab/axitinib Pembrolizumab/lenvatinib Nivolumab/ipilimumab |
Cabozantinib Sunitinb pazopanib |
