Table 3.
Role of miRNAs in Cancer immune escape [127].
| miRNA | Effect/Mechanism | Cancer Types |
|---|---|---|
| miR-24-3p | Increased T reg cells activity and reduced Th17 proliferation via targeting fibroblast growth factor 11 | Nasopharyngeal cancer |
| miR-183 | Reduced the activity of NK cells | Lung cancer |
| miR-23a | Reduced activity of CD8+ cells via acting on B lymphocyte-induced maturation protein-1 | |
| miR-155 | Reduced activity of MDSCs via acing on hypoxia inducing factor-α | pancreatic cancer |
| miR-212-3p | Increased immune response of DC via acting on Regulatory Factor X Associated Protein | |
| miR-92a-3p | Increased tumor-associated macrophages and IL-6 level | Liposarcoma |
| miR-25-3p | Increased tumor-associated macrophages and IL-6 level | |
| miR-155 | Reduced activity of MDSCs via acing on hypoxia inducing factor-α | Skin cancer |
| miR-210 | Reduced activity of MDSCs via acing on C-X-C motif chemokine 12 and IL-16 | |
| miR-34a | Reduced recruitment of T reg cells via acting on C-X-C motif chemokine 12 | Hepatic cancer |
| miR-20a and miR-17-5p | Reduced activity of MDSCs via acing on Reduced activity of MDSCs via acing on C-X-C motif chemokine 12 and IL-16 | Colon cancer |
| miR-494 | Reduced activity of MDSCs via acing on Phosphatase and tensin homolog | Breast cancer |
| miR-222-3p | Increased polarization of M2 macrophage via acting on suppressor of cytokine signaling 3 | Ovarian cancer |