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The NPM1-ALK fusion protein produced due to a t(2;5)(p23;q35) chromosomal translocation. The kinase domain, depicted in red, is the site within the ALK portion of the fusion protein where ALK tyrosine kinase inhibitors (ALK TKIs) bind. Mutations here can lead to ALK TKI resistance [15,16]. AAs = amino acids, TM = transmembrane, TK = tyrosine kinase.
