Table 8.
Main results regarding levels of cytokines of included studies.
| Author (year) | Thymectomized patients compared to controls | P value |
|---|---|---|
| Silva et al. (2017b) (28) | IL-7 (LT vs control) 12.8* (5.3-16.2) a vs 15.0* (6.5-23.3) a |
<0.05 |
| Van den Broek et al. (2017) (7) | ↑ IFN-γ, IL-17, IL-13, TNFα, CXCL 13; NSS IL-21 (1-5 years after Tx) |
<0.05 |
| Van den Broek et al. (2016) (10) | ↓ IL-8; NSS IL-2 (1-5 years after Tx) | <0.05 |
| Zlamy et al. (2016) (29) | NSS IL-7 | – |
| Sauce et al. (2012) (27) | ↑ IL-7 | 0.03 |
| Cao et al. (2011) (20) | NSS IL-2, IL-4, IFN-γ | – |
| Van Gent et al. (2011) (16) | ↑ IL-7 (in the first 2.5 years after Tx) | 0.012 |
| Sauce et al. (2009) (24) | ↑ IL-1β, IL-8 and eotaxin | <0.005 |
| Mancebo et al. (2008) (21) | IL-7 (1 year and 2 years after Tx vs control) 11.1* (±9.9) b and 13.9* (±11.4) b vs 3.8* (±3.1) b |
<0.01 |
NSS, not statistically significant; Tx, thymectomy.
a
Results are shown as median and ranges in brackets.
b
Results are shown as mean ± standard deviation in brackets.
*pg/ml.
↑, higher; ↓ lower.