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. 2021 Nov 25;12:772276. doi: 10.3389/fphys.2021.772276

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Copyright © 2021 Cheng, Gao, Sun and Mathias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aquaporin 0 (Aqp0, green) and phalloidin (F-actin, red) staining in cross sections from control, EphA2^–/– and ephrin-A5^–/– lenses. Images are from the periphery to the inner mature fiber cells of the lens. (A) In control peripheral lens fibers, Aqp0 is added to the cell membrane and evenly distributed around the membrane. As the cells mature, Aqp0 is enriched on the short sides of the fiber cells. In EphA2^–/– peripheral fiber cells, there are large puncta/aggregates of Aqp0 (pound signs), and as the cells mature, Aqp0 is distributed around the cell membrane without enrichment along the short sides of the cells (asterisks and high magnification panels on the right). (B) Compared to control fibers, Aqp0 distribution in differentiating and maturing ephrin-A5^–/– fibers is around the entire cell membrane (asterisks and high magnification panels on the right) while Aqp0 is enriched along the short sides of control lens fibers. Scale bars, 20 and 5 μm.