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. 2021 Nov 25;11:780365. doi: 10.3389/fcimb.2021.780365

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Copyright © 2021 Yu, Xiong, Luo, Chen, Ji, Ying, Liu and Xiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative inhibition ratios (CIRs) of ceftazidime (CAZ) and aztreonam (ATM) with increased avibactam concentration against ceftazidime–avibactam (CZA)-resistant carbapenem-resistant organisms (CROs) and carbapenem-resistant Pseudomonas aeruginosa (CR-Pae) with a high-level minimum inhibitory concentration (MIC) of aztreonam–avibactam (AZA). (A) CZA against CZA-resistant carbapenem-resistant Escherichia coli (CR-Eco). (B) AZA against CZA-resistant CR-Eco. (C) CZA against CZA-resistant carbapenem-resistant Klebsiella pneumoniae (CR-Kpn). (D) AZA against CZA-resistant CR-Kpn. (E) CZA against CZA-resistant CR-Pae. (F) AZA against CZA-resistant CR-Pae. (G) CZA against CR-Pae with the high-level MIC of AZA. (H) AZA against CR-Pae with the high-level MIC of AZA.