Table 2.
Top 25 chromatin regulator genes amplified in urothelial carcinoma.
| HGNC Gene Symbol | HGNC Gene Name | Function | Sample Number with Amplifications | Cytoband |
|---|---|---|---|---|
| USP21 | ubiquitin specific peptidase 21 | Histone modification erase | 69 | 1q23.3 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | Histone modification read | 69 | 8q22.3 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | Chromatin remodeling, Histone modification write cofactor | 58 | 8q22.3 |
| TADA1 | transcriptional adaptor 1 | Histone chaperone | 46 | 1q24.1 |
| SETDB1 | SET domain, bifurcated 1 | Histone modification write | 44 | 1q21.3 |
| BRD9 | bromodomain containing 9 | Histone modification read | 42 | 5p15.33 |
| TAF3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kDa | Histone modification read | 41 | 10p14 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | Chromatin remodeling | 40 | 1q21.1 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | Histone modification write cofactor | 40 | 1q21.1 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | Histone modification write cofactor | 40 | 1q21.3 |
| ZNF687 | zinc finger protein 687 | Histone modification erase cofactor | 40 | 1q21.3 |
| POGZ | pogo transposable element with ZNF domain | Histone modification read | 39 | 1q21.3 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | Histone chaperone, Histone modification read | 38 | 1q21.2 |
| TDRKH | tudor and KH domain containing | RNA modification | 38 | 1q21.3 |
| SETD5 | SET domain containing 5 | Histone modification write | 38 | 3p25.3 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | Histone modification write cofactor | 38 | 8p11.23 |
| HDAC11 | histone deacetylase 11 | Histone modification erase | 37 | 3p25.1 |
| BRPF1 | bromodomain and PHD finger containing, 1 | Histone modification read | 37 | 3p25.3 |
| TADA3 | transcriptional adaptor 3 | Histone modification write cofactor | 37 | 3p25.3 |
| ATAD2 | ATPase family, AAA domain containing 2 | Chromatin remodeling | 35 | 8q24.13 |
| ZHX1 | zinc fingers and homeoboxes 1 | Chromatin remodeling, Histone modification write cofactor | 35 | 8q24.13 |
| SFMBT2 | Scm-like with four mbt domains 2 | Histone modification read, Polycomb group (PcG) protein, TF | 35 | 10p14 |
| NIPBL | Nipped-B homolog (Drosophila) | Histone modification erase cofactor | 33 | 5p13.2 |
| YEATS4 | YEATS domain containing 4 | Histone modification write cofactor | 33 | 12q15 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | Chromatin remodeling | 32 | 8q22.1 |