Figure 2.

Regulatory networks involving miR-200 family. miR-200 family members play a key role as repressors of factors driving EMT (green boxes) and stemness (blue box), two key hallmarks of tumor progression and invasive growth. The miR-200 family lies at the core of multiple double negative feedback loops (DNFL, indicated by yellow shaded areas) controlling EMT plasticity: one direct with the ZEB and SNAIL transcription factors, the other indirect through signaling pathways that control ZEB and SNAIL. Additional miR-200-based DNFL control Myc and SIRT1, two pervasive regulators of the cell’s transcriptional landscape. White boxes indicate major positive and negative cues controlling miR-200 expression. EMT, epithelial-mesenchymal transition. MET, mesenchymal-epithelial transition.