Table 1.
Clinical and molecular characteristics of ependymomas based on tumor location.
| Anatomical Location | Molecular Subgroup | Genetic Characteristics | Histopathology (WHO Grade) | Age | Gender | Outcome |
|---|---|---|---|---|---|---|
| Supratentorial (ST) | SE | Balanced | Sub-ependymoma (WHO I) | Adulthood | >M | Good |
| EPN-YAP1 | Aberr. 11q | Classic/Anaplastic (WHO II-III) | Infancy to childhood | >F | Good | |
| EPN-RELA | Aberr. 11q | Classic/Anaplastic (WHO II-III) | Infancy to childhood | >M | Poor | |
| Posterior fossa (PF) | SE | Balanced | Sub-ependymoma (WHO I) | Adulthood | >M | Good |
| EPN-A | Balanced | Classic/Anaplastic (WHO II-III) | Infancy | >M | Poor | |
| EPN-B | CIN | Classic/Anaplastic (WHO II-III) | Childhood to Adulthood | >F | Good | |
| Spinal (SP) | SE | 6q del. | Sub-ependymoma (WHO I) | Childhood to Adulthood | M = F | Good |
| MPE | CIN | Mixopapillary Ependymoma (WHO I) | Adulthood | M = F | Good | |
| EPN | CIN | Classic/Anaplastic (WHO II-III) | Adulthood | >M | Good |
SE = subependymoma; EPN = ependymoma; MPE = mixopapilalry ependymoma; M = males; F = females.