Table 4.
Prognostic molecular parameters.
| Analyzed Molecular Factors |
N. of Patients |
Association with Histological Grade | Association with Survival | Reference |
|---|---|---|---|---|
| COX-2, HER-2, EGFR, MUC2, Ki67 | 65 | EGFR, Ki67 | Ki67 | [51] |
| p53/KRAS Mutations a | 194/64 | p53 | p53 | [52] |
| dMMR, MUC b, Ki67, p53 | 155 | - | - | [53] |
| CEA, Ki67 and p53 | 141 | Ki67, p53 | Ki67, p53 | [54] |
| Ki67, p53 | 117 | Ki67 | Ki67 | [55] |
a All molecular markers were analyzed by IHC, except for KRAS, whose mutations in codons 12 and 13 were analyzed by shifted termination assay; b IHC staining for MUC1, MUC2, MUC5AC and MUC6.