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. 2021 Aug 1;17(8):1695–1705. doi: 10.5664/jcsm.9308

Figure 1. Study flowchart.

Figure 1

*Other reasons for withdrawal from the study were as follows: patients who did not decline the therapy or withdraw their consent but declined to return to follow-up visits at the hospital (these patients could not be considered as lost to follow-up because they answered phone calls; n = 19); MAD-treated patients who did not withdraw their consent but moved out of the area during the follow-up period (n = 7); patients effectively treated with an MAD but who preferred surgery or other therapy to treat their OSA during follow-up (n = 6); patients who stopped MAD because of another pathology (eg, cancer, depression; n = 3); patients who stopped MAD therapy because of weight loss that resolved their OSA (n = 1); death (n = 1); patient with dental treatment not linked to MAD therapy who did not want to resume study treatment (n = 1); and patient file lost by center (n = 1). CAD/CAM = computer-aided design/computer-aided manufacturing, CPAP = continuous positive airway pressure, ITT = intention-to-treat, MAD = mandibular advancement device.