Table 2.
Patient characteristics.
| Number of Clearance Studies | Total 38 |
<2 Years 18 |
>2 Years 20 |
p-Value |
|---|---|---|---|---|
| Age, years | 2.2 [0.5–3.3] | 0.5 [0.4–1.0] | 3.3 [3.0–4.0] | <0.001 |
| Body weight, kg | 13.5 [8.8–15.7] | 8.6 [6.2–9.5] | 15.6 [14.8–16.5] | <0.001 |
| BSA, m2 | 0.60 [0.41–0.66] | 0.40 [0.33–0.43] | 0.65 [0.63–0.67] | <0.001 |
| BMI, kg/m2 | 15.9 [15.1–18.6] | 17.9 [14.7–18.9] | 15.6 [15.1–16.4] | 0.11 |
| Creatinine, mg/dL a | 0.27 [0.22–0.32] | 0.25 [0.18–0.29] | 0.31 [0.24–0.33] | 0.008 |
| Cystatin C, mg/L | 0.80 [0.74–0.97] | 0.97 [0.86–1.09] | 0.75 [0.69–0.79] | <0.001 |
| eGFR-Schwartzcrea (mL/min/1.73 m2) | 104.3 [92.8–120.7] | 95.2 [82.6–116.7] | 108.9 [99.9–125.3] | <0.001 |
| eGFR-Schwartzcrea abs (mL/min) | 36.0 [21.7–43.0] | 21.7 [19.1–26.6] | 42.7 [39.3–44.9] | <0.001 |
| eGFR-Brandt (mL/min/1.73 m2) | 115.4 [97.9–128.7] | 97.8 [85.2–106.0] | 128.6 [123.4–138.9] | <0.001 |
| eGFR-Brandt abs (mL/min) | 43.5 [22.1–49.4] | 22.0 [18.6–24.0] | 49.2 [46.9–52.1] | <0.001 |
| eGFR-Millisor (mL/min/1.73 m2) | 103.4 [89.2–124.5] | 92.2 [76.9–119.3] | 109.2 [98.0–130.5] | <0.001 |
| eGFR-Millisor abs (mL/min) | 35.8 [21.7–43.3] | 21.3 [18.2–26.9] | 42.6 [37.8–46.4] | <0.001 |
| eGFR-Schwartzcys (mL/min/1.73 m2) | 99.7 [84.1–107.4] | 83.8 [75.3–94.2] | 106.6 [100.9–114.7] | <0.001 |
| eGFR-Schwartzcys abs (mL/min) | 33.6 [18.1–40.9] | 18.0 [13.8–24.4] | 40.6 [38.0–44.0] | <0.001 |
| eGFR-FAScys (mL/min/1.73 m2) | 109.4 [91.1–118.5] | 90.7 [80.8–102.9] | 117.6 [110.8–127.1] | <0.001 |
| eGFR-FAScys abs (mL/min) | 37.2 [19.6–45.2] | 19.4 [14.7–26.7] | 44.8 [41.7–48.7] | <0.001 |
| eGFR-Berg (mL/min/1.73 m2) | 118.5 [94.9–130.6] | 94.5 [82.1–110.1] | 129.3 [120.3–142.2] | <0.001 |
| eGFR-Berg abs (mL/min) | 41.3 [20.2–49.9] | 20.1 [14.8–28.5] | 49.2 [45.0–54.6] | <0.001 |
| Observed carboplatin clearance (mL/min/1.73 m2) | 104.3 [83.6–122.9] | 84.5 [75.3–106.2] | 116.7 [90.3–136.1] | 0.002 |
| Observed carboplatin clearance abs (mL/min) | 33.4 [18.8–45.4] | 18.7 [15.9–27.9] | 44.4 [37.3–49.3] | <0.001 |
| Observed carboplatin AUC (mg/mL.min) | 7.9 [7.0–8.6] | 7.7 [6.4–8.5] | 8.2 [7.3–10.7] | 0.09 |
a To convert to µmol/L multiply by 88.4. BMI: body mass index, BSA: body surface area, eGFR: estimated glomerular filtration rate.