Figure 5.

Intra-tumoral heterogeneity in intracranial ependymoma by scRNA-seq. scRNA-seq of tumor cells is colored based on distinct gene signatures that define cell subpopulations. The relative frequency of each subpopulation is different in PFA tumors that are enriched for undifferentiated cells vs. PFB tumors enriched for ependymal-like cells. ST-RELA tumors also harbor high fractions of progenitor cell subpopulations, whereas a distinct ST-YAP1 gene signature is overrepresented in ST-YAP1. Some overlap between transcriptional signatures is observed across EPN groups.