Table 1.
miRNAs showing altered expression in extracellular compartments and tissues in UM patients.
| miRNAs | Plasma | Serum | Exosomes from Liver Perfusate | Vitreous Humor | Tissue |
|---|---|---|---|---|---|
| miR-106a | up after interferon-alfa-2b therapy [81] | ||||
| miR-107 | up in patients [82] | ||||
| miR-16 | up after interferon-alfa-2b therapy [81] | up in localized and metastatic UM [83] | up in high-risk patients [84] | ||
| miR-124 | up in patients [82] | ||||
| miR-125b | up in UM and metastatic patients [85] | ||||
| miR-126 | down after interferon-alfa-2b therapy [81] | ||||
| miR-145 | up in localized and metastatic UM [83] | ||||
| miR-146a | up in UM and metastatic patients [85] | up in serum and serum exosomes of UM patients [12] | up in vitreous humor and vitreal exosomes of UM patients [12] | up in UM tissue [12] | |
| up in localized and metastatic UM [83] | highest expression in UM patients [38] | ||||
| up in serum of UM patients [86] | up in UM tissue [86] | ||||
| miR-155 | up in UM and metastatic patients [85] | ||||
| miR-16 | up after interferon-alfa-2b therapy [81] | up in localized and metastatic UM [83] | up in high-risk patients [84] | ||
| miR-181a | up in UM patients; down in metastatic patients [85] | down in patients with poor survival [87] | |||
| miR-199a | down after interferon-alfa-2b therapy [81] | up in patients with high risk of metastasis [88] | |||
| up in patients with high risk of metastasis [89] | up in monosomy of chromosome 3 [90] | ||||
| down in metastatic patients [91] | |||||
| up in high grade UM [37] | |||||
| miR-20a | up in UM and metastatic patients [85] | ||||
| miR-204 | up in localized UM [83] | ||||
| miR-21 | up in vitreous humor and vitreal exosomes of UM patients [12] | up in UM tissue [12] | |||
| up in high risk of metastasis [84] | |||||
| miR-210 | up in patients [82] | ||||
| miR-211 | up in localized and metastatic UM [83] | down in UM tissue [92] | |||
| miR-223 | up in UM and metastatic patients [85] | ||||
| up in patients with high risk of metastasis [89] | |||||
| miR-26a | highest expression in UM patients [38] | ||||
| miR-320a | up in patients [82] | ||||
| miR-34a | up in vitreous humor and vitreal exosomes of UM patients [12] | up in UM tissue [12] | |||
| highest expression in UM patients [38] | |||||
| miR-363-3p | up in localized and metastatic UM [83] | ||||
| miR-370 | up in patients [82] | ||||
| miR-486-5p | up in patients [82] | ||||
| miR-532-5p | highest expression in UM patients [38] | ||||
| miR-618 | up in serum of UM patients compared to unaffected individuals [12] | down in vitreous and up in vitreal exosomes of UM patients [12] | |||
| miR-92b | up in patients with high risk of metastasis [89] |