Table 2.
Compounds able to modulate the expression of miR-199a, miR-16, miR-211, and miR-146a. Degree and eccentricity values (centrality metric parameters necessary for the identification of nodes important for network stability) were calculated by using Cytoscape Network Analysis. Degree: number of connections of each node with the others; eccentricity: the maximum distance from a node to any other node of the network.
| Degree | Eccentricity | Name |
|---|---|---|
| 4 | 4 | Doxorubicin |
| 1 | 6 | Pyrrolidine dithiocarbamate |
| 1 | 6 | Resveratrol |
| 2 | 4 | 5-fluorouracil |
| 1 | 6 | 5-aza-2′-deoxycytidine (5-Aza-CdR) |
| 1 | 6 | 5-aza-2′-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) |
| 2 | 4 | Cisplatin |
| 1 | 6 | Bortezomib |
| 1 | 6 | Calcium sulfate (CaS) |
| 3 | 4 | Enoxacin |
| 2 | 4 | Curcumin |
| 3 | 4 | Arsenic trioxide |
| 1 | 6 | Estrogen |
| 1 | 6 | All-trans-retinoic acid (ATRA) |
| 1 | 6 | Melphalan |
| 2 | 6 | Nicotine |
| 2 | 4 | Glucose |
| 1 | 6 | Trypaflavine |
| 1 | 6 | Marine fungal metabolite 1386A |
| 2 | 6 | Morphine |
| 2 | 6 | Trichostatin A (TSA) |
| 2 | 6 | Benzo(a)pyrene |
| 2 | 6 | Glucocorticoid |
| 1 | 6 | Formaldehyde |
| 1 | 6 | Ginsenoside Rh2 |
| 1 | 6 | Polylysine |
| 1 | 6 | Diethylstilbestrol |
| 3 | 4 | Gemcitabine |
| 2 | 6 | Bisphenol A |
| 1 | 6 | Fluoxetine |
| 1 | 6 | Genistein |
| 1 | 6 | Vincristine |
| 1 | 6 | Tamoxifen |
| 1 | 6 | Nutlin |
| 2 | 6 | 17beta-estradiol (E2) |
| 1 | 6 | Microcystin-LR (MC-LR) |
| 1 | 6 | CDF(analogues of curcumin) |
| 1 | 6 | Imatinib mesylate |
| 1 | 6 | Vitamin D3 |
| 1 | 6 | Phorbol 12-myristate 13-acetate (PMA) |
| 1 | 6 | Prednisone |
| 1 | 6 | 1,2,6-Tri-O-galloyl-beta-D-glucopyranose |
| 1 | 6 | 3-nitropropionic acid (3-NPA) |
| 1 | 6 | Activin A |
| 1 | 6 | Oltipraz |
| 1 | 6 | Paclitaxel |
| 1 | 4 | Ethanol |
| 1 | 4 | Emodin |
| 1 | 4 | Heparin |