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. 2021 Nov 26;13(23):5946. doi: 10.3390/cancers13235946

Figure 9.

Figure 9

CARMA3/YAP/NF-κB/Slug signaling pathway is associated with a poor prognosis for human colorectal cancer. (A) Kaplan–Meier plot of overall survival of colorectal cancer patients with high and low YAP1 expression (p < 0.05, log-rank test, HR = 1.82, Dataset: GSE17536). (B,C) Kaplan–Meier plot of disease-free survival of colorectal cancer patients with high and low RELA (p < 0.05, log-rank test, HR = 12.85) or SNAI2 expression (p < 0.05, log-rank test, HR = 1.71, Dataset: GSE17536). (D,E) The correlation between CARD10 and YAP1 expression or YAP1 and RELA expression in intestine cancer patients from the Correlation AnalyzeR database. Statistics from individual studies were obtained from the Correlation AnalyzeR database. The genes correlation (Pearson’s R) and p values were shown within each box plot. (F) The correlation between YAP1 and SNAI2 expression in colon cancer patients was analyzed from Oncomine datasets: Bittner_Colon. Statistics from individual studies were obtained from the Oncomine cancer database. The correlation coefficient (r), sample number (N), and p values were shown within the box plot. (G) A schematic model illustrating CARMA3/YAP/NF-κB/Slug pathway in CRC cells was shown. CARAM3 induces expression of YAP to activate NF-κB and induction of Slug, resulting in the enhancement of EMT, cancer stemness, and metastasis in CRC.