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Correlation between BRAF gene copy number alteration and mutant allele frequency in BRAF mutant metastases.
| BRAF | Copy Number State (N) | |||
|---|---|---|---|---|
| CN2 (7) | CN3 (11) | CN4 (2) | CN5 (2) | |
| MAF * (mean ± SE) | 27.00 ± 5.16 | 46.36 ± 6.63 | 61.60 ± 7.50 | 52.25 ± 21.25 |
| heterozygous | 1 | 2 | 1 | 0 |
| homozygous | 0 | 3 | 1 | 1 |
| subclonal | 6 | 6 | 0 | 1 |
| Correlation coefficient ** (p-value) | 0.540 (0.009) | |||
Asterisks represent: * mutant allele frequency, ** Spearman’s Rho correlation, two-tailed.
