TABLE 1.
Characteristics of patients eligible in this study.
| Characteristic | Number of cases (%) | |
| Training cohort (N = 264) | SYSUCC-001 cohort (N = 86) | |
| Age (years) at diagnosis | — | — |
| ≤50 | 151 (57.2) | 64 (74.4) |
| >50 | 113 (42.8) | 22 (25.6) |
| Median | 48 | 43.5 |
| Interquartile range | 41–57 | 37–51 |
| Menopausal status | — | — |
| Premenopausal | 169 (64.0) | 68 (79.1) |
| Postmenopausal | 95 (36.0) | 18 (20.9) |
| Histological type | — | — |
| Invasive ductal carcinoma | 261 (98.9) | 86 (100.0) |
| Others | 3 (1.1) | 0 |
| Histological grade a | — | — |
| 1 | 6 (2.3) | 1 (1.2) |
| 2 | 110 (41.7) | 16 (18.6) |
| 3 | 148 (56.1) | 69 (80.2) |
| Lymphovascular invasion | — | — |
| No | 209 (79.2) | 71 (82.6) |
| Yes | 55 (20.8) | 15 (17.4) |
| Ki-67 index at diagnosis <30% b | — | — |
| No | 201 (76.1) | 74 (86.0) |
| Yes | 63 (23.9) | 12 (14.0) |
| T stage c | — | — |
| 1 | 90 (34.1) | 29 (33.7) |
| 2 | 145 (54.9) | 53 (61.6) |
| 3 | 23 (8.7) | 2 (2.3) |
| 4 | 6 (2.3) | 2 (2.3) |
| N stage c | — | — |
| 0 | 153 (58.0) | 52 (60.5) |
| 1 | 60 (22.7) | 19 (22.1) |
| 2 | 27 (10.2) | 6 (7.0) |
| 3 | 24 (9.1) | 9 (10.5) |
| Serum copper (μmol/L) d | — | — |
| ≤21.3 | 237 (89.8) | 84 (97.7) |
| >21.3 | 27 (10.2) | 2 (2.3) |
a
Histological grade at diagnosis was based on the degree of histological tumor differentiation.
b
The Ki-67 index at diagnosis indicates DNA, synthetic activity as measured using immunocytochemistry.
c
Diagnosed based on the AJCC, 2016 criteria (eighth edition).
d
Cut-off values were determined using maximally selected log-rank statistics.