Table 2.
Pro and anti-tumor properties of neutrophils and their role in tumor process.
| Phenotype | Neutrophil Component | Tumor Process | References |
|---|---|---|---|
| N2 (Pro-tumor) | MMP9, VEGF, BV8 | Angiogenesis | [44,69,70] |
| ARG1, INOS, CCL17 | Suppression of immune cells | [71,72] | |
| HGF, OSM | Cancer metastasis | [73,74] | |
| NE, PGE2, NETs | Cancer growth | [75,76] | |
| ROS, H2O2 | Carcinogenesis | [72] | |
| N1 (anti-tumor) | ROS, HOCL | Tumor cell lysis | [77] |
| TRAIL | Tumor cell apoptosis | [78] | |
| ADCC | Tumor cell cytotoxicity | [79] | |
| TNFα, NE, IFN-γ | Promote T cell proliferation | [80] | |
| Cathepsin G | H2O2 dependent tumor cell cytotoxicity | [81] |
Legend: MMP: matrix metalloproteinase; VEGF: vascular endothelial growth factor; ARG1: arginase 1; INOS: inducible nitric oxide synthases; CCL7: C-C motif chemokine ligand 7; HGF: hepatocyte growth factor; OSM: oncostatin M; NE: neutrophil elastase; PGE: prostaglandin E2; ROS: reactive oxygen species; H2O2: hydrogen peroxide; HOCL: hypochlorous acid; TRAIL: tumor necrosis factor-related apoptosis-inducing ligand; ADCC: antibody dependent cellular cytotoxicity.