Table 2.

Treatment with 1 µM AZD2858 leads to the deregulation of genes associated with mitosis in the patient-derived cell line GBM1 as determined in an expression microarray (top hits are shown in the table). The highlighted genes in grey are genes with known functions in mitosis.

Average Expression	LOGFC	p-Value	FDR	Probe	Systematic Name	Symbol	Entrez
14.4	−0.39	1.47 × 10−7	6.58 × 10−6	A_33_P3317523	NM_203401	STMN1	3925
14.0	0.40	7.76 × 10−11	1.49 × 10−8	A_24_P322444	NM_153719	NUP62	23636
13.2	−0.26	1.50 × 10−5	0.00026	A_23_P206059	NM_003981	PRC1	9055
12.8	−0.50	2.10 × 10−8	1.42 × 10−6	A_23_P406424	NM_175744	RHOC	389
12.1	−0.60	8.53 × 10−11	1.60 × 10−8	A_33_P3350488	NM_016359	NUSAP1	51203
12.1	−0.27	2.21 × 10−5	0.00036	A_23_P48835	NM_138555	KIF23	9493
11.6	0.24	6.76 × 10−5	0.00091	A_23_P100868	NM_001033580	MYO19	80179
11.6	−0.41	1.47 × 10−6	4.08 × 10−5	A_23_P420551	NM_007174	CIT	11113
11.1	−0.33	2.28 × 10−6	5.78 × 10−5	A_33_P3298356	NM_001206651	SH3GLB1	51100
11.1	−0.34	5.33 × 10−5	0.00075	A_23_P115872	NM_018131	CEP55	55165
11.0	−0.39	1.12 × 10−7	5.26 × 10−6	A_23_P89410	NM_003766	BECN1	8678
10.9	−0.36	5.94 × 10−5	0.00082	A_23_P115872	NM_018131	CEP55	55165
10.5	−0.25	5.71 × 10−5	0.00080	A_23_P65930	NM_001077268	ZFYVE19	84936
10.1	−0.55	1.07 × 10−6	3.17 × 10−5	A_23_P35399	NM_145869	ANXA11	311
10.0	−0.88	6.59 × 10−7	2.16 × 10−5	A_23_P18939	NM_002890	RASA1	5921
9.6	0.26	2.99 × 10−6	7.19 × 10−5	A_33_P3421748	ENST00000381679	SON	6651
9.1	0.60	2.85 × 10−5	0.00044	A_33_P3288110	NM_001005476	PKP4	8502
8.8	−0.44	4.34 × 10−5	0.00063	A_33_P3257140	NM_004850	ROCK2	9475
8.7	0.52	6.76 × 10−6	0.00014	A_24_P286935	NM_004311	ARL3	403
7.8	0.42	2.79 × 10−6	6.79 × 10−5	A_24_P173124	NM_144997	FLCN	201163
7.1	−0.27	5.76 × 10−5	0.00080	A_23_P254404	NM_153271	SNX33	257364