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Interaction of CD26 with adenosine deaminase (ADA). Extracellular adenosine (Ado) interferes with T-cell receptor signaling by binding to the adenosine receptor 2a (A2aR) expressed on T cells (A). ADA anchored to CD26 metabolizes immunosuppressive adenosine to inosine (Ino) and in this way facilitates T-cell activation and differentiation to effector/memory T cells.
