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. 2021 Dec 2;13(23):6081. doi: 10.3390/cancers13236081

Figure 4.

Figure 4

Next generation sequencing (NGS) results of a sinonasal carcinoma collective. A total of 136 FFPE samples from sinonasal tumors, from 90 male and 46 female individuals, were analyzed by next generation-targeted sequencing. Age at diagnosis ranged from 23 to 93 years (mean age 61 years, SD 13 years) (cases that were WT in all tested gene regions were not shown). EGFR mutations were significantly associated with ISP and SP-associated carcinomas, whereas TP53 mutations could be detected in many different tumor types. In contrast to PIK3CA mutations, KRAS and EGFR mutations were mutually exclusive. HPV positive cases predominantly carried a WT sequence in the EGFR gene.