Table 1.
Post-RT body weights, organ weights, and tibia lengths at weeks 1, 3, and 15.
| Parameter (Unit) | Week 1 | Week 3 | Week 15 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | RT | RT Los | Control | RT | RT Los | Control | RT | RT Los | |
| Body weight at the beginning (g) | 233 ± 8 | 233 ± 5 | 232 ± 4 * | 282 ± 5 | 281 ± 7 | 282 ± 6 | 261 ± 3 | 263 ± 4 | 261 ± 5 |
| Body weight at the endpoint (g) | 269 ± 7 | 258 ± 6 | 251 ± 5 * | 382 ± 9.57 | 338 ± 5.22 * | 344 ± 8.8 * | 525 ± 14 | 377 ± 29 * | 414 ± 17 * |
| Tibia length (cm) | 3.39 ± 0.06 | 3.36 ± 0.03 | 3.33 ± 0.04 | 3.83 ± 0.07 | 3.73 ± 0.05 | 3.86 ± 0.09 | 4.5 ± 0.04 | 4.25 ± 0.08 * | 4.28 ± 0.04 * |
| Heart weight (g) | 0.91 ± 0.02 | 0.87 ± 0.03 | 0.87 ± 0.02 | 1.16 ± 0.03 | 1.1 ± 0.04 | 1.06 ± 0.05 | 2.24 ± 0.11 | 1.75 ± 0.04 * | 1.63 ± 0.11 * |
| Left ventricle weight (g) | 0.62 ± 0.01 | 0.57 ± 0.02 * | 0.55 ± 0.02 * | 0.77 ± 0.02 | 0.69 ± 0.02 * | 0.66 ± 0.02 * | 1.3 ± 0.05 | 0.99 ± 0.03 * | 0.88 ± 0.06 * |
| Right ventricle weight (g) | 0.17 ± 0.01 | 0.17 ± 0.01 | 0.18 ± 0.01 | 0.24 ± 0.01 | 0.25 ± 0.01 | 0.23 ± 0.02 | 0.35 ± 0.01 | 0.33 ± 0.01 | 0.32 ± 0.02 |
| Lung weight (g) | 1.3 ± 0.02 | 1.29 ± 0.05 | 1.3 ±0.03 | 1.7 ± 0.12 | 2.98 ± 0.26 * | 2.47 ± 0.29 * | 1.64 ± 0.04 | 1.88 ± 0.32 | 1.50 ± 0.1 |
Values are presented as mean ± S.E.M., * p < 0.05 vs. control group, (n = 6–7, One-Way ANOVA, Holm-Sidak post hoc test). RT: radiotherapy only group (50 Gy), RT Los: RT plus losartan group.