Table 3.
Echocardiographic parameters according to treatment groups at weeks 1, 3, and 15.
| Parameter (Unit) | Week 1 | Week 3 | Week 15 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | RT | RT Los | Control | RT | RT Los | Control | RT | RT Los | |
| E velocity (m/s) | 1.00 ± 0.04 | 0.94 ± 0.05 | 0.90 ± 0.04 | 1.00 ± 0.04 | 1.05 ± 0.03 | 0.93 ± 0.04 # | 1.01 ± 0.02 | 0.81 ± 0.10 * | 0.75 ± 0.05 * |
| e’ (m/s) | 0.060 ± 0.002 | 0.053 ± 0.001 * | 0.063 ± 0.005 | 0.066 ± 0.006 | 0.038 ± 0.002 * | 0.056 ± 0.005 # | 0.077 ± 0.007 | 0.035 ± 0.002 * | 0.042 ± 0.002 * |
| SWTs (mm) | 2.70 ± 0.10 | 2.84 ± 0.16 | 2.91 ± 0.10 | 3.14 ± 0.15 | 3.47 ± 0.12 | 3.18 ± 0.14 | 3.58 ± 0.12 | 4.64 ± 0.17 * | 4.29 ± 0.32 |
| SWTd (mm) | 1.61 ± 0.10 | 1.60 ± 0.09 | 1.90 ± 0.06 | 1.79 ± 0.12 | 1.73 ± 0.06 | 1.77 ± 0.14 | 1.83 ± 0.04 | 3.23 ± 0.33* | 3.12 ± 0.28 |
| AWTs (mm) | 2.64 ± 0.17 | 2.61 ± 0.09 | 2.92 ± 0.20 | 2.85 ± 0.17 | 3.19 ± 0.18 | 2.89 ± 0.27 | 3.3 ± 0.23 | 4.56 ± 0.28 * | 4.51 ± 0.17 * |
| AWTd (mm) | 1.63 ± 0.17 | 1.51 ± 0.07 | 1.75 ± 0.09 | 1.61 ± 0.07 | 1.67 ± 0.11 | 1.67 ± 0.09 | 1.99 ± 0.13 | 3.14 ± 0.31 * | 3.04 ± 0.17 * |
| IWTs (mm) | 2.24 ± 0.13 | 2.47 ± 0.08 | 2.70 ± 0.10 * | 2.67 ± 0.07 | 3.32 ± 0.17 * | 2.91 ± 0.23 | 3.44 ± 0.25 | 4.56 ± 0.09 * | 3.69 ± 0.31 |
| IWTd (mm) | 1.48 ± 0.03 | 1.51 ± 0.09 | 1.67 ± 0.09 | 1.73 ± 0.07 | 1.98 ± 0.07 * | 1.90 ± 0.15 | 2.01 ± 0.12 | 3.67 ± 0.12 * | 2.72 ± 0.26 *# |
| LVEDD (mm) | 7.73 ± 0.22 | 7.34 ± 0.27 | 6.98 ± 0.16 * | 8.33 ± 0.2 | 7.4 ± 0.14 * | 7.11 ± 0.29 * | 8.44 ± 0.33 | 4.85 ± 0.17 * | 5.67 ± 0.29 *# |
| LVESD (mm) | 4.75 ± 0.21 | 4.05 ± 0.28 | 3.68 ± 0.21 * | 4.83 ± 0.17 | 3.40 ± 0.20 * | 3.25 ± 0.25 * | 4.26 ± 0.55 | 0.98 ± 0.15 * | 1.63 ± 0.16 * |
| FS (%) | 39 ± 2 | 45 ± 2 * | 48 ± 2 * | 42 ± 2 | 54 ± 2 * | 54 ± 2 * | 50 ± 5 | 80 ± 3 * | 71 ± 3 * |
| EF (%) | 56 ± 2 | 57 ± 3 | 52 ± 1 | 53 ± 2 | 53 ± 3 | 53 ± 1 | 53 ± 2 | 57 ± 2 | 55 ± 1 |
Values are presented as mean ± S.E.M., * p < 0.05 vs. control group, # p < 0.05 vs. RT group (n = 6–7, One-Way ANOVA, Holm-Sidak post hoc test). RT: radiotherapy only group (50 Gy), RT Los: RT plus losartan group. AWT: anterior wall thickness, d: diastolic, E: early flow velocity, e’: velocity of the septal mitral annulus, EF: ejection fraction, FS: fractional shortening, IWT: inferior wall thickness, LVEDD: left ventricular end-diastolic diameter, LVESD: left ventricular end-diastolic diameter, s: systolic, SWT: septal wall thickness.