Figure 2.

Cancer treatment strategies involving ROCK. ROCK is involved in multiple steps of the cell cycle and DNA damage response. ROCK further plays an important role in all stages of cancer cell metastasis including the formation of filopodia and lamellipodia, cytoskeletal reprogramming, EMT process, and the regulation of TME components. ROCK also activates pro-tumorigenic CAFs and increases the deposition of ECM components. This increase in ECM deposition promotes its stiffness and rigidity to exert tumor cell progression. Finally, ROCK inhibition combined with other chemotherapeutic agents can induce a synergistic antitumor effect.