Figure 6.

C-ImmSim presentation of an in silico immune simulation with the construct. (A) Immunoglobulin production in response to antigen injections (black vertical lines); specific subclasses are shown as colored peaks and (B) The evolution of B-cell populations after the three injections. (C) T-helper cell populations per state after the injections. (D) The evolution of T-cytotoxic cells. (E) Production of natural killer cells. The resting state represents cells not presented with the antigen while the anergic state characterizes tolerance of the T-cells to the antigen due to repeated exposures. (F) The main plot shows cytokine levels after the injections. The insert plot shows IL-2 level with the Simpson index. D is shown by the dotted line. D is a measure of diversity. Increase in D over time indicates emergence of different epitope-specific dominant clones of T-cells. The smaller the D value, the lower the diversity.