Figure 2.

Fly central brain neural stem cell lineages express different transcription factors and can be transformed by the misregulation of even a single gene. The type I and type II neural stem cell lineages in the larval fly brain generate neurons via different division patterns. Multiple transcription factors behave as type II identity genes, and their overexpression in type I neuroblasts is sufficient to transform a type I neuroblast into a type II neuroblast. Similarly, the loss of these identity genes can transform a type II neuroblast into a type I neuroblast.