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. 2021 Nov 26;22(23):12806. doi: 10.3390/ijms222312806

Figure 5.

Figure 5

Top3β−/− mice display neurological defects, lower muscle strength, and altered neuromuscular function. Prepulse-inhibition test was performed with 10 week old mice. Both male (A) and female (B) Top3β−/− mice showed reduced percentage of PPI. Grip strengths for forelimb (C) and combined forelimb and hindlimb (D) were measured for Top3β−/− and Top3β+/+ mice at 9 weeks old. Female Top3β−/− mice showed reductions for both grip strengths, while male Top3β−/− mice did not show reduced forelimb grip strength. Six mice per group were used. A rotarod test was carried out with 10 week old Top3β−/− male (E) and female (F) mice. The latency until falling off from the start on the accelerating rod was measured with three trials (interval of 15 min). Both sexes of Top3β−/− mice showed decreased latency. n = 6 for each group. * p < 0.05; ** p < 0.01.