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. 2021 Nov 26;22(23):12806. doi: 10.3390/ijms222312806

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Functional correlation map in different regions of Top3β^−/− mice brains by PET/CT image analysis. Metabolic correlation in brains of Top3β^−/− mice was determined from (¹⁸F-FDG) PET analysis. Top3β^−/− mice showed altered metabolic correlation in different nodes of brain regions. Red lines and blue lines indicate increased and decreased correlations between two brain regions of 53 VOIs, respectively (p < 0.005, p < 0.01, and p < 0.05 vs. WT mice, n = 7 mice per group). A; olfactory bulb, B; optic nerve, C; globus pallidus, D; amygdala, E; cerebellum. L; left, R; right.