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The TGFβ1 large latent complex (LLC): The LLC is made up of the LAP (blue), TGFβ1 (grey), and LTBP (black). The LAP is linked to the LTBP by disulfide linkages (dotted lines). As a result of contraction mediated by ανβ6 integrin, LAP and TGFβ1 can be proteolytically separated (red arrow). Dissociation of LAP from TGFβ1 allows for the endogenous release of TGFβ1. Information adapted from [48].
