Figure 6.

In vivo blocking of CXCR3 alters the CXCL9- mediated CD4⁺ T cells chemotaxis in Gba1^9V/− mice. WT and Gba1^9V/− mice were injected with intraperitoneal administration of CXCL9 and its vehicle as described in the method. In additional experiments, these mice were injected with intravenous injection of mouse anti-CXCR3 antibodies prior to intraperitoneal injection of CXCL9 or vehicle and the peritoneal cells were collected and analyzed by FACS. The dot plots and the corresponding bar diagrams represent the percentage of migrated CD3⁺CD4⁺ T cells in WT (a–e) and Gba1^9V/− mice (e–i). WT (black columns), Gba1^9V/− (maroon columns) and the values shown are the mean ± SD. and group comparison were performed with ANOVA. Three independent experiments were conducted (ns, not significant; ***, p < 0.001, ****, p < 0.0001).