Table 1.

Genetic variants within the TNF-α/NF-κB pathway and psoriatic disease features.

Genetic Variant	Disease Feature
CARD14 rsll652075 (p. Arg820Trp)	-Increased risk of developing psoriasis [16,17,18,19,20]. Good anti-TNFα drug response among CC genotype carriers [40].
TNFSRF1B rs1061622 (p. Met196Arg)	-Increased risk of developing psoriasis conditioned by HLA-Cw6 positivity [23]. Worse response to anti-TNFα drugs among G genotype carriers [23].
NFKB1 * rs28362491 (−94 of ATTG) NFKB1 rs7667496/rs28362491	-No apparent association with disease risk and/or disease phenotypes [27]. Increased risk for coronary artery disease [51]. -Type 2 diabetes. Impaired renal function [48].
NFKBIA rs7152376 C (complete LD with rs12883343)	-Significant association with PsA [33,34] -Risk of myocardial infarction and several IMIDs [28,29]. -Increased psoriasis risk [30,31,32]. Increased psoriasis risk [30,31,32].
NFKBIZ rs7637230 NFKBIZ rs3217713 ins/ins NFKBIZ rs3217713 del/del	-Increased risk of developing psoriasis [36]. -Increased risk of developing psoriasis conditioned by HLA-Cw6 positivity [37]. Insertion allele more frequent among anti-TNFα non-responders, with a recessive effect [42]. -Early-onset coronary artery disease [50].

* Other variants located at the chromosomal region where NFKB1 is found have been investigated and related to psoriasis risk, specifically rs1020760 (also associated with a positive family history) and rs1609798 [25,26]. LD: linkage disequilibrium. IMIDs: immune-mediated inflammatory diseases. CARD14: caspase recruitment domain family member 14 gene. TNFSRF1B: Type 2-TNFα receptor gene. NFKB1: NFκB subunit 1 gene. NFKBIA: NFκB alpha-inhibitor gene. NFKBIZ: NFκB zeta-inhibitor gene.