Table 1.
Toll-like receptors expressed in human pancreatic cancer cell lines.
| TLRs | Localization | PAMPs | Adaptor | Pancreatic Cancer Cell Line | Refs. |
|---|---|---|---|---|---|
| TLR1 | Plasma membrane | Triacyl lipopeptides | Myd88/TIRAP | Not reported | [19,32] |
| TLR2 | Plasma membrane | Lycolipids, lipoprotein, lipoteichoic acid, peptidoglycan, zymosan | Myd88/TIRAP | BxPC-3; MIA PaCa-2, MDA Panc-28, SU 8686, SW-1990, AsPC-1, Panc-1 | [19,33,34,35] |
| TLR3 | Endosome | Double-stranded RNA | TRIF | AsPC-1, Colo357, Panc-89, PancTu-1, Pt45P1 | [36,37,38] |
| TLR4 | Plasma membrane | Lipopolysaccharide (LPS), heat shock proteins | Myd88/TIRAP | AsPC-1, BxPC-3, CFPAC, MIA PaCa-2, MDA Panc-28, Panc-1, Sw-1990 | [34,35,39] |
| TLR5 | Plasma membrane | Flagellin | Myd88 | Not reported | [32] |
| TLR6 | Plasma membrane | Diacyl lipopeptides, lipoteichoic acid | Myd88/TIRAP | Not reported | [32] |
| TLR7 | Endosome | Single-stranded RNA | Myd88 | Colo357, MIA PaCa-2, MDA Panc-28, Panc-1, Sw-1990, Panc-89, PancTu-1, BxPC-3 | [38,40,41,42] |
| TLR8 | Endosome | Single-stranded RNA | Myd88 | Panc-1 | [41] |
| TLR9 | Endosome | DNA (CpG) | Myd88 | GER, MIA PaCa-2, MDA Panc-28, Panc-1, Sw-1990, T3M4 | [34,43,44] |
| TLR10 | Endosome | Unknown | Unknown | Not reported | [32] |