Table 4.
List of antagonists of TLRs.
| Drug Name | Target | Drug Class | Refs. |
|---|---|---|---|
| TAK-242 (Resatorvid) | TLR4 | Small molecule inhibitor | [150] |
| CRX-526 | TLR4 | Synthetic lipopolysaccharide | [163] |
| CX-01 | TLR4 | heparin-derived olysaccharide | [164] |
| CXC195 | TLR4 | tetramethylpyrazine analogue | [165] |
| Eritoran (E5564) | TLR4 | Synthetic lipopolysaccharide | [168] |
| Atractylenolide-1 | TLR4 | sesquiterpene compound | [169] |
| Triptolide | TLR4 | diterpenoid epoxide | [170] |
| Paeonol | TLR4 | Small molecule inhibitor | [171] |
| NI-0101 | TLR4 | Monoclonal antibody | [172] |
| Nalmefene (JKB-121) | TLR4 | Small molecule inhibitor | [173] |
| Ibudilast (AV-411, N-166) | TLR4 | Small molecule inhibitor | [174] |
| Polymyxin B (PMB) | TLR4 | Cyclic polypeptide antibiotic | [175] |
| OPN305 | TLR2 | Monoclonal antibody | [176] |
| Hydroxychloroquine | TLR7,9 | Quinolone | [177] |