Table 4.
Multivariate analysis of 21-day disease progression probability of the PS-matched cohort.
| Factors for disease progression | O2 support | Progression to severe disease | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age ≥ 70 years | 1.120 (0.507-2.476) | 0.779 | ||
| Sx onset to admission, days | 1.233 (1.052–1.445) | 0.010 | ||
| SIRS | 1.699 (0.885–3.262) | 0.111 | ||
| SpO2 < 97%* | 3.847 (2.111–7.011) | <0.001 | 2.829 (1.186–6.747) | 0.019 |
| Thrombocytopenia (<150 x103/μL) | 2.864 (1.563–5.250) | <0.001 | 1.909 (0.814–4.478) | 0.003 |
| Albumin < 4.0 g/dL | 1.875 (0.752–4.679) | 0.178 | ||
| BUN elevation (>19 mg/dL) | 1.490 (0.628–3.535) | 0.366 | ||
| LDH, IU/L | 1.004 (1.001–1.008) | 0.025 | ||
| LDH elevation (>400 IU/L) | 1.813 (0.984–3.339) | 0.056 | ||
| CRP elevation (>5 mg/dL) | 3.613 (1.569–8.319) | 0.003 | 5.881 (1.843–18.771) | 0.003 |
| Cardiovascular disease | 3.456 (1.617–7.385) | 0.001 | ||
| Diabetes mellitus | 1.684 (0.874–3.243) | 0.119 | ||
| Hypertension | 1.546 (0.853–2.802) | 0.151 | ||
| Regdanvimab treatment | 0.548 (0.301–0.999) | 0.050 | 0.176 (0.060–0.516) | 0.002 |
*Median value of total cohort.
HR, hazard ratio; CI, confidence interval; Sx, symptom; SpO2, saturation of percutaneous oxygen; BUN, blood urea nitrogen; LDH, lactate dehydrogenase; CRP, C-reactive protein.