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FP receptor antagonist promoted lung edema. AL8810 (10 mg/kg, i.p.) was administered to mice at 1 h before HCl (0.1 M, 2 µL/g, i.t.) administration. (A) Lung wet/dry weight ratio was calculated (n = 6–7). (B) The gene expression levels of ENaC in the lungs of saline-, HCl-, and HCl+AL8810-treated mice were determined by qPCR (n = 5–7). * p < 0.05 vs. saline, # p < 0.05 vs. HCl.
