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Inhibition of FP receptors on HUVECs enhanced the disruption of endothelium barriers. HUVECs were stimulated with 100 ng/mL LPS for 24 h. AL8810 was treated at 30 min before LPS stimulation (n = 3). The expression levels of FP receptors (A), ICAM-1, and E-selectin (B) were measured by qPCR. * p < 0.05 vs. no-treated cells, # p < 0.05, as shown by brackets. N.D.: not detected.
