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. 2021 Nov 23;22(23):12656. doi: 10.3390/ijms222312656

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Electrophysiological characterisation of NMDAR-mediated currents in HEK-293T heterologously expressing disease-associated GRIN1-DNVs. (Top) Representative electrophysiological traces of NMDAR-mediated currents in HEK-293T cells transfected with biallelic GRIN1-DNVs (or GRIN1-wt) and GRIN2B and co-activaded by simultaneous 5-sec (bar) application of 50 μM glycine and 1 mM glutamate. (Bottom) Summary of functional annotations of GluN1-DNVs. Data representing mean ± SEM. ns non-significant statistical difference; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; NA, not assigned. Note: statistically significant differences in bold characters.

Electrophysiological characterisation of NMDAR-mediated currents in HEK-293T heterologously expressing disease-associated GRIN1-DNVs. (Top) Representative electrophysiological traces of NMDAR-mediated currents in HEK-293T cells transfected with biallelic GRIN1-DNVs (or GRIN1-wt) and GRIN2B and co-activaded by simultaneous 5-sec (bar) application of 50 μM glycine and 1 mM glutamate. (Bottom) Summary of functional annotations of GluN1-DNVs. Data representing mean ± SEM. ns non-significant statistical difference; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; NA, not assigned. Note: statistically significant differences in bold characters.