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. 2021 Nov 25;12:706936. doi: 10.3389/fimmu.2021.706936

Figure 2.

Figure 2

Construction, evaluation, and comparison of a risk signature. (A) LASSO coefficient profiles of the 17 irlncRNAs in the training set. (B) A coefficient profile plot was generated against the log (lambda) sequence. Selection of the optimal parameter (lambda) in the LASSO model. (C, D) The AUC value and cutoff point obtained in the training set. (E) Forest plot of 17 irlncRNAs selected by univariate Cox regression analysis associated with GBM survival in the training set. (F) Forest plot of six irlncRNAs selected by multivariate Cox regression analysis associated with GBM survival and construction risk model. (G) Risk score and survival status analysis of irlncRNAs prognostic signature. (H) The expression pattern of irlncRNAs prognostic signature in the low- and high-risk groups. (I) Survival analysis of irlncRNAs prognostic signature. (J) ROC curve analysis within 1, 2, and 3 years. (K) Multivariate ROC curve analysis showing that the superior prognostic performance of the irlncRNAs prognostic model compared to other clinical indicators. (L) AUCs of the ROCs for our and the three other gene signatures.