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. 2021 Nov 25;12:764746. doi: 10.3389/fimmu.2021.764746

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Copyright © 2021 Azamor, Cunha, da Silva, Bezerra, Ribeiro-Alves, Calvo, Kehdy, Manta, Pinto, Ferreira, Portari, Guida, Gomes, Moreira, de Carvalho, Cardoso, Muller, Ano Bom, Neves, Vasconcelos and Moraes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Event-based flowchart of CZS occurrence. The trimester of pregnancy in which first Zika symptoms occur and newborn genotypes of rs2257167 were used as independent variables to determine the association with CZS outcome. Total number of newborns with full information of both trimesters of infection and rs2257167 genotypes (n=125) was used to calculate the absolute number of newborns per group (n) and CZS percentage. Concerning infections in the first trimester of pregnancy, we found that irrespective of rs2257167 genotypes, 66% of the cases developed CZS, in contrast with second and third trimesters. Considering rs2257167, newborn CG/CC genotype seems to be associated with CZS risk in the second and third trimesters.