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. 2021 Nov 25;12:764746. doi: 10.3389/fimmu.2021.764746

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Copyright © 2021 Azamor, Cunha, da Silva, Bezerra, Ribeiro-Alves, Calvo, Kehdy, Manta, Pinto, Ferreira, Portari, Guida, Gomes, Moreira, de Carvalho, Cardoso, Muller, Ano Bom, Neves, Vasconcelos and Moraes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZIKV infection leads to an immunological imbalance in placenta. Placental gene expression profile in healthy (N = 10) versus ZIKV-infected women (N = 74). Each dot corresponds to one placenta analyzed. The number of dots varies according to gene analyzed due to failed amplifications. Median and standard deviation of gene expression values are normalized by the housekeeping genes selected by the geNorm and NormFinder as well as 18S ribosomal RNA and RLP13 ribosomal protein L13 (grey boxes). Values are adjusted by mothers’ age (below or equal to/above 40 years of age) and trimester of infection (the trimester of pregnancy in which the first Zika symptoms occur or asymptomatic ZIKV infections). P-values ** ≤ 0.01, * ≤ 0.05 and ≤ 0.1.