AD |
Alzheimer’s disease |
Aβ |
Amyloid-β proteins |
APP |
Amyloid-β precursor protein |
NFTs |
Neurofibrillary tangles |
CNS |
Central nervous system |
PNS |
Peripheral nervous system |
MTs |
Microtubules |
ROS |
Reactive oxygen species |
PHFs |
Paired helical filaments |
nAChRs |
Nicotinic acetylcholine receptors |
mAChRs |
Muscarinic acetylcholine receptors |
ACh |
Acetylcholine |
sAPPα |
Soluble amyloid precursor protein–α |
CTF |
C-terminal fragment |
AICD |
APP intracellular domain |
PI3K |
Phosphatidylinositol 3 kinase |
MAPK |
Mitogen activated protein kinase |
ERK |
Extracellular signal regulated kinase |
PKC |
Protein kinase C |
cAMP-PKA |
Cyclic AMP–protein kinase A |
LTD |
Long-term depression |
LTP |
Long-term potentiation |
CSF |
Cerebrospinal fluid |
BACE |
β-Site APP cleaving enzyme |
ADDLs |
Amyloid-β-derived diffused ligands |
NMDA |
N-Methyl-D-aspartate |
AβOs |
Aβ oligomers |
GPCRs |
G-protein-coupled receptors |
cAMP |
Cyclic adenosine monophosphate |
DAG |
Diacylglycerol |
IP3 |
Inositol 1,4,5-triphosphate |
GSK3β |
Glycogen synthase kinase 3β |
5-HT |
Serotonin; 5 hydroxytryptamine |
NP |
Norepinephrine |
GAPs |
GTPase activating proteins |
AChE |
Acetylcholinesterase |
AChEi |
Acetylcholinesterase inhibitors |
α-BTX |
α-Bungarotoxin |
JNK-1 |
c-Jun N-terminal kinase |
VDCCs |
Voltage-dependent calcium channels |
GABA |
γ-Aminobutyric acid |
GAD |
Glutamic acid decarboxylase |
vGAT |
Vesicular GABA transporter |
KCC2 |
Potassium chloride co-transporter 2 |
CGN |
Cerebellar granule neuron |
ERK/mTOR |
Extracellular-signal-regulated kinase/ mechanistic target of rapamycin |
PP2A |
Protein phosphatase 2A |
Cdk5 |
Cyclin-dependent kinase 5 |
DG |
Dentate gyrus |
PLC |
Phospholipase C |
SSRI |
Serotonin reuptake inhibitors |
IAPP |
Islet amyloid polypeptide |
RAMP |
Receptor activity modifying protein |
CT |
Calcitonin |
T2DM |
Type 2 diabetes mellitus |
AMY3 |
Amylin-3 receptor |
CTR |
Calcitonin receptor |
HFNs |
Human fetal neurons |
TRPV4 |
Transient receptor potential cation channel subfamily V member 4 |
LTAD |
Late-onset Alzheimer’s disease |
RGP |
Rabies virus glycoprotein |
3FTx |
Three-finger toxin |