Table 1.

A: List of prior publications and sensitivity/specificity analysis on MSA study for the initial detection of bladder cancer. B: List of prior publications and sensitivity/specificity analysis on MSA study for the recurrent disease detection (surveillance setting) of bladder cancer.

A
Study	No. of Cancers Detected	Sensitivity	Healthy Controls with Neg MSA Result	Specificity
	by MSA	(%)		(%)
Mao et al. (1996) ♦ Science 271:659–662	19/20	95	5 out of 5	100
Wild et al. (2009) ♦ Cancer Epidemiol. Biomark. Prev, 18, 1798–1806	71/81	88	37 out of 38	97
Linn et al. (1997) ♦ Int J Cancer 74:625–629	13/15	87	N/A	N/A
Schneider et al. (2000) ♦ Cancer Res 60:4617–4622	87/103	84	N/A	N/A
Sourvinos et al. (2001) ♦ J Urol 165:249–252	26/28	93	10 out of 10	100
Zhang et al. (2001) ♦ Cancer Lett. 172:55–58	73/81	90	19/19	100
Seripa et al. (2001) ♦ Int J Cancer 95:364–369	33/34	97	11 out of 11	100
Zhang et al. (2001) ♦ JNCI 93:45–50	22/23	96	17/17	100
van Rhijn et al. (2003) ♦ Clin. Cancer Res. 9, 257–263	29/32	91	14 out of 15	93
OVERALL	373/417	90%	113/115	98%
B
Study	No. of Cancers Detected	Sensitivity	Healthy Controls with Neg MSA Result	Specificity
	by MSA	(%)		(%)
van Rhijn et al. (2001) ♦ Cancer 92:768–775.e 271:659–662	23/29	79	66 out of 70	94
Steiner et al. (1997) ♦ Nat Med. 3:621–624	10/11	91	10 out of 10	100
Baron et al. (2000) ♦ Adv Clin Path.4 (1):19–24	21/25	84	N/A	N/A
Bartoletti et al. (2005) ♦ Oncol Rep;13:531–537	25/30	84	30 out of 30	100
Bartoletti et al. (2006) ♦ J Urol175:2032–2037	59/73	81	36 out of 43	84
Bas et al. (2003) ♦ European Urology 43, 369–373		83		93
Frigerio et al. (2007) ♦ Int. J. Cancer Res, 121, 329–338	59/63	93	28 out of 28	100
Mourah et al. (1998) ♦ Int. J. Cancer Res. 79, 629–633.	10/12	96	15 out of 15	100
Amira et al. (2002) ♦ Int J Cancer 101:293–297	44/47	94	N/A	N/A
OVERALL	251/290	87%	185/196	94%