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. 2021 Nov 27;22(23):12844. doi: 10.3390/ijms222312844

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative figure showing morphological abnormalities of islets of Langerhans in experiment 1: (A,B) exocrine gland extends into swelled islet of Langerhans. Red circle shows original region of islet endocrine cells. The area circled by blue shows invasion of exocrine cells. These areas are shown in (C) as a schema. These islets were evaluated as “mild morphological change” (HE staining). (D) Swollen islet of Langerhans was constructed by beta-cells with abundant insulin (IHC of insulin). This islet was evaluated as “no change”. (E) Exocrine gland extended into swollen islet of Langerhans. Swollen islet of Langerhans was constructed by mixture of beta-cells with weak insulin (IHC of insulin) and exocrine gland. This islet was evaluated as “mild morphological change”. (F) Exocrine gland severely extended into swollen islet of Langerhans. Scattered beta-cells (IHC of insulin) were observed within originally swollen islet of Langerhans. This islet was evaluated as “severe morphological change”. Scale bar: 200 μm.