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. 2021 Dec 1;22(23):13026. doi: 10.3390/ijms222313026

Figure 1.

Figure 1

PCSK9 only slightly affects the expression of chemokine receptors on blood leukocytes and subtypes in vivo. The expression of antibodies used for CXCR4, CCR8, CCR5 and CCR2 were tested on leukocytes in the blood of C57/BL6 mice and compared to unstained leukocytes to represent the efficiency of the antibodies (A). The expression levels of chemokine receptors was measured using flow cytometry and represented using geometric mean (Geo.Mean) in blood leukocytes (B), classical monocytes (C), non-classical monocytes (D), neutrophils (E), B cells (F) and T cells (G) of PCSK9 over-expressing mice (n = 8) and compared to control mice (n = 8). Bar graphs are representation of mean ± SEM. ** p < 0.01, *** p < 0.001. The statistical difference between the groups was calculated using 2-way ANOVA tests in GraphPad Prism.