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. 2021 Dec 1;22(23):13026. doi: 10.3390/ijms222313026

Figure 7.

Figure 7

PCSK9 marginally affects the expression of chemokine receptors in human coronary artery endothelial cells while considerably increasing the secretion of IL6. The expression of chemokine receptors CXCR4, CCR8, CCR5, and CCR2 were measured using flow cytometry and represented using geometric mean (Geo.Mean) in HCAECs (n = 3–4 replicates) with and without PCSK9 (A) and when exposed to an inflammatory environment with LPS (B). Inflammatory cytokines IL6 (C) and TNF-α (D) expressions measured in the supernatant of the cell culture with and without PCSK9 in an inflammatory environment (n = 3–4 replicates). Bar graphs are representation of mean ± SEM. *** p < 0.001, **** p < 0.0001. 2-way ANOVA was used for (A,B), and the Mann–Whitney test was used for (C,D) to calculate the statistical differences.