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. 2021 Dec 1;22(23):13026. doi: 10.3390/ijms222313026

Figure 8.

Figure 8

PCSK9 has no effect on the chemokine receptors and cytokines in human aortic smooth muscle cells. The expression of chemokine receptors CXCR4, CCR8, CCR5, and CCR2 were measured using flow cytometry and represented using geometric mean (Geo.Mean) in HAoSMCs (n = 3–4 replicates) with and without PCSK9 (A) and when exposed to an inflammatory environment with LPS (B). Inflammatory cytokines IL6 (C) and TNF-α (D) expressions measured in the supernatant of the cell culture with and without PCSK9 in an inflammatory environment (n = 3–4 replicates). Bar graphs are representation of mean ± SEM. 2-way ANOVA was used for (A,B) and thee Mann–Whitney test was used for (C,D) to calculate the statistical differences.