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Schematic representation of aging- and senescence-related changes in skin associated with apoptosis. Bcl-2, B cell lymphoma 2; Fas, cell surface death receptor; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; PDL-1, programmed death-ligand 1; ROS, reactive oxygen species; SASP, senescence-associated secretory phenotype.
