Figure 6.

Liver S-palmitoylated proteins involved in urea cycle. Each protein is represented by a circle with center reflecting the HPDpalm/RDpalm values and the periphery–the HPDp/RDp values at 4 and 12 weeks (abbreviated as 4W and 12W) of feeding. Coloring marks up-regulation (green) or down-regulation (red) or no change (grey) of the extent of S-palmitoylation or the protein level in HPD vs. RD livers. HPDp/RDp and HPDpalm/RDpalm values of the proteins are shown in Supplemental Table S3, sheet 4. Enzymes of the urea cycle are shown on yellow background. Aspartate can be derived by transamination of oxaloacetate from the TCA cycle while fumarate can enter the TCA cycle as an anaplerotic substrate.